M6PR Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component:  clathrin-coated vesicle membrane; endosome; integral component of plasma membrane; late endosome; lysosomal membrane; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network membrane; transport vesicle
Molecular Function:  protein binding; protein domain specific binding; retromer complex binding; transmembrane signaling receptor activity
Biological Process:  endosome to lysosome transport; lysosomal transport; membrane organization; receptor-mediated endocytosis; secretion of lysosomal enzymes
Reference #:  P20645 (UniProtKB)
Alt. Names/Synonyms: 46 kDa mannose 6-phosphate receptor; 46-kDa mannose 6-phosphate receptor; Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-M6PR; CD-MPR; FLJ32994; M6PR; mannose-6-phosphate receptor (cation dependent); mannose-6-phosphate receptor, cation dependent; MPR 46; MPR-46; MPR46; MPRD; Mr 46,000 Man6PR; small mannose 6-phosphate receptor; SMPR
Gene Symbols: M6PR
Molecular weight: 30,993 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB