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M6PR
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
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Cellular Component:
endosome; Golgi apparatus; late endosome; lysosomal membrane; perinuclear region of cytoplasm
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Molecular Function:
protein domain specific binding; retromer complex binding
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Biological Process:
lysosomal transport; secretion of lysosomal enzymes
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Reference #:
P11456
(UniProtKB)
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Alt. Names/Synonyms: 46 kDa mannose 6-phosphate receptor; Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-MPR; M6PR; MPR 46; MPRD
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Gene Symbols: M6PR
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Molecular weight:
31,201 Da
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Basal Isoelectric point:
5.44
Predict pI for various phosphorylation states
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