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CCR7
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Belongs to the G-protein coupled receptor 1 family. Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR |
| Chromosomal Location of Human Ortholog: 11|11 D |
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Cellular Component:
cell surface; external side of plasma membrane; integral component of membrane; membrane; mitochondrion; plasma membrane
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Molecular Function:
C-C chemokine binding; C-C chemokine receptor activity; C-C motif chemokine 19 receptor activity; C-C motif chemokine 21 receptor activity; chemokine (C-C motif) ligand 19 binding; chemokine (C-C motif) ligand 21 binding; chemokine binding; chemokine receptor activity; G protein-coupled receptor activity; protein binding
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Biological Process:
actin cytoskeleton organization; activation of JUN kinase activity; calcium-mediated signaling; cell chemotaxis; cellular response to cytokine stimulus; chemotaxis; establishment of T cell polarity; G protein-coupled receptor signaling pathway; homeostasis of number of cells; immune response; inflammatory response; interleukin-12 secretion; lymph node development; lymphocyte chemotaxis across high endothelial venule; lymphocyte migration into lymph node; mature conventional dendritic cell differentiation; myeloid dendritic cell chemotaxis; negative regulation of leukocyte apoptotic process; negative thymic T cell selection; positive regulation of cell motility; positive regulation of cytosolic calcium ion concentration; positive regulation of dendritic cell antigen processing and presentation; positive regulation of dendritic cell chemotaxis; positive regulation of filopodium assembly; positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation; positive regulation of GTPase activity; positive regulation of humoral immune response; positive regulation of hypersensitivity; positive regulation of immunological synapse formation; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-12 production; positive regulation of macrophage chemotaxis; positive regulation of neutrophil chemotaxis; positive regulation of phagocytosis; positive regulation of receptor-mediated endocytosis; positive regulation of T cell chemotaxis; positive regulation of T cell costimulation; positive regulation of T cell proliferation; positive regulation of T cell receptor signaling pathway; positive regulation of T-helper 1 cell differentiation; positive regulation of thymocyte migration; positive regulation of tumor necrosis factor production; regulation of dendritic cell dendrite assembly; regulation of interferon-gamma production; regulation of interleukin-1 beta secretion; regulation of tolerance induction to self antigen; response to lipopolysaccharide; response to nitric oxide; response to prostaglandin E; signal transduction
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Reference #:
P47774
(UniProtKB)
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Alt. Names/Synonyms: C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR-7; Ccr7; CD197; Cdw197; chemokine (C-C motif) receptor 7; chemokine (C-C) receptor 7; Cmkbr; Cmkbr7; EBI; EBI1; Ebi1h; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus-induced G-protein coupled receptor 1; MIP-3 beta receptor; OTTMUSP00000006846
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Gene Symbols: Ccr7
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Molecular weight:
42,856 Da
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Basal Isoelectric point:
8.92
Predict pI for various phosphorylation states
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