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CCR7
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Belongs to the G-protein coupled receptor 1 family. Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 17q21.2 |
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Cellular Component:
cell surface; external side of plasma membrane; mitochondrion; plasma membrane
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Molecular Function:
C-C chemokine binding; C-C chemokine receptor activity; C-C motif chemokine 19 receptor activity; C-C motif chemokine 21 receptor activity; chemokine (C-C motif) ligand 19 binding; chemokine (C-C motif) ligand 21 binding; G protein-coupled receptor activity
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Biological Process:
activation of GTPase activity; calcium-mediated signaling; cell chemotaxis; cellular response to cytokine stimulus; chemokine (C-C motif) ligand 19 signaling pathway; chemokine (C-C motif) ligand 21 signaling pathway; dendritic cell chemotaxis; establishment of T cell polarity; G protein-coupled receptor signaling pathway; homeostasis of number of cells; immune response; inflammatory response; lymphocyte migration into lymph node; mature conventional dendritic cell differentiation; myeloid dendritic cell chemotaxis; negative regulation of dendritic cell apoptotic process; negative regulation of interleukin-12 production; negative thymic T cell selection; positive regulation of actin filament polymerization; positive regulation of cell adhesion; positive regulation of cell motility; positive regulation of cell-matrix adhesion; positive regulation of cytosolic calcium ion concentration; positive regulation of dendritic cell antigen processing and presentation; positive regulation of dendritic cell chemotaxis; positive regulation of ERK1 and ERK2 cascade; positive regulation of filopodium assembly; positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation; positive regulation of humoral immune response; positive regulation of hypersensitivity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of immunological synapse formation; positive regulation of interleukin-12 production; positive regulation of JNK cascade; positive regulation of neutrophil chemotaxis; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of pseudopodium assembly; positive regulation of T cell costimulation; positive regulation of T cell receptor signaling pathway; regulation of dendritic cell dendrite assembly; regulation of interleukin-1 beta production; regulation of type II interferon production; release of sequestered calcium ion into cytosol; response to lipopolysaccharide; response to nitric oxide; response to prostaglandin E; ruffle organization
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Reference #:
P32248
(UniProtKB)
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Alt. Names/Synonyms: BLR2; Bukitt's lymphoma receptor 2; C-C chemokine receptor type 7; C-C CKR-7; C-C motif chemokine receptor 7; CC chemokine receptor 7; CC-CKR-7; CCR-7; CCR7; CD197; CDw197; chemokine (C-C motif) receptor 7; chemokine (C-C) receptor 7; CMKBR7; EBI1; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced G-protein coupled receptor; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor
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Gene Symbols: CCR7
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Molecular weight:
42,874 Da
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Basal Isoelectric point:
8.82
Predict pI for various phosphorylation states
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