AEBP1 Isoform 1: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellualr matrix. Isoform 2: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. Expressed in osteoblast and visceral fat. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Transcription factor
Chromosomal Location of Human Ortholog: 11|11 A1
Cellular Component:  cytoplasm; extracellular region; extracellular space; nucleus
Molecular Function:  calmodulin binding; carboxypeptidase activity; collagen binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; metallocarboxypeptidase activity; RNA polymerase II regulatory region sequence-specific DNA binding; transcription corepressor activity; zinc ion binding
Biological Process:  negative regulation of transcription by RNA polymerase II; peptide metabolic process; protein processing; proteolysis; regulation of collagen fibril organization; regulation of transcription, DNA-templated
Reference #:  Q640N1 (UniProtKB)
Alt. Names/Synonyms: Aclp; Adipocyte enhancer-binding protein 1; AE binding protein 1; AE-binding protein 1; Aebp1; Aortic carboxypeptidase-like protein; OTTMUSP00000005314
Gene Symbols: Aebp1
Molecular weight: 128,365 Da
Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene