SSH1 Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. Belongs to the protein-tyrosine phosphatase family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Protein phosphatase, dual-specificity
Chromosomal Location of mouse Ortholog: 5|5 F
Cellular Component:  cell leading edge; cell projection; cytoplasm; cytoskeleton; cytosol; growth cone; plasma membrane
Molecular Function:  actin binding; hydrolase activity; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
Biological Process:  actin cytoskeleton organization; cell morphogenesis; cellular response to ATP; dephosphorylation; excitatory chemical synaptic transmission; negative regulation of actin filament polymerization; positive regulation of AMPA glutamate receptor clustering; positive regulation of excitatory postsynaptic potential; positive regulation of neuron death; positive regulation of synaptic plasticity; positive regulation of vascular associated smooth muscle cell migration; protein dephosphorylation; regulation of cellular protein metabolic process
Reference #:  Q76I79 (UniProtKB)
Alt. Names/Synonyms: AW551225; Gm1394; Gm1395; Kiaa1298; mSSH; mSSH-1L; OTTMUSP00000031415; Protein phosphatase Slingshot homolog 1; slingshot 1L; slingshot homolog 1 (Drosophila); slingshot protein phosphatase 1; slingshot-like 1; SSH-1; SSH-1L; SSH-like protein 1; Ssh1; Ssh1l
Gene Symbols: Ssh1
Molecular weight: 115,297 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene