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SSH1
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. Belongs to the protein-tyrosine phosphatase family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity |
| Chromosomal Location of mouse Ortholog: 5|5 F |
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Cellular Component:
cell leading edge; cell projection; cytoplasm; cytoskeleton; cytosol; growth cone; plasma membrane
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Molecular Function:
actin binding; hydrolase activity; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
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Biological Process:
actin cytoskeleton organization; cell morphogenesis; cellular response to ATP; dephosphorylation; excitatory chemical synaptic transmission; negative regulation of actin filament polymerization; positive regulation of AMPA glutamate receptor clustering; positive regulation of excitatory postsynaptic potential; positive regulation of neuron death; positive regulation of synaptic plasticity; positive regulation of vascular associated smooth muscle cell migration; protein dephosphorylation; regulation of cellular protein metabolic process
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Reference #:
Q76I79
(UniProtKB)
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Alt. Names/Synonyms: AW551225; Gm1394; Gm1395; Kiaa1298; mSSH; mSSH-1L; OTTMUSP00000031415; Protein phosphatase Slingshot homolog 1; slingshot 1L; slingshot homolog 1 (Drosophila); slingshot protein phosphatase 1; slingshot-like 1; SSH-1; SSH-1L; SSH-like protein 1; Ssh1; Ssh1l
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Gene Symbols: Ssh1
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Molecular weight:
115,297 Da
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Basal Isoelectric point:
6.23
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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