CACNA1E Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily. Expressed in neuronal tissues and in kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 1 G3|1 66.14 cM
Cellular Component:  GABA-ergic synapse; integral component of membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; membrane; perikaryon; voltage-gated calcium channel complex
Molecular Function:  calcium channel activity; calcium ion binding; ion channel activity; metal ion binding; protein N-terminus binding; voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels; voltage-gated ion channel activity
Biological Process:  behavioral fear response; behavioral response to pain; calcium ion import; calcium ion transmembrane transport; calcium ion transport; chemical synaptic transmission; fear response; flagellated sperm motility; glucose homeostasis; ion transport; locomotory behavior; nervous system process; regulation of heart rate; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of ion transmembrane transport; regulation of somatostatin secretion; response to pain; sensory perception of pain; transmembrane transport; transmission of nerve impulse; visual learning
Reference #:  Q61290 (UniProtKB)
Alt. Names/Synonyms: A430040I15; alp; alpha1E; BII; Brain calcium channel II; CAC1E; Cach6; Cacna1e; Cacnl1a6; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide, isoform 6; calcium channel, voltage-dependent, L type, alpha 1E subunit; calcium channel, voltage-dependent, R type, alpha 1E subunit; Cav2; Cav2.3; Cchr; Cchra1; Voltage-dependent R-type calcium channel subunit alpha-1E; Voltage-gated calcium channel subunit alpha Cav2.3
Gene Symbols: Cacna1e
Molecular weight: 257,236 Da
Basal Isoelectric point: 8.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene