CACNA1E Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily. Expressed in neuronal tissues and in kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 1q25.3
Cellular Component:  neuronal cell body; plasma membrane; synapse; voltage-gated calcium channel complex
Molecular Function:  calcium ion binding; high voltage-gated calcium channel activity; voltage-gated calcium channel activity; voltage-gated monoatomic cation channel activity
Biological Process:  calcium ion import across plasma membrane; chemical synaptic transmission; regulation of monoatomic ion transmembrane transport
Disease: Epileptic Encephalopathy, Early Infantile, 69
Reference #:  Q15878 (UniProtKB)
Alt. Names/Synonyms: BII; Brain calcium channel II; CAC1E; CACH6; CACNA1E; CACNL1A6; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide, isoform 6; calcium channel, R type, alpha-1 polypeptide; calcium channel, R type, alpha-1 polypeptide, isoform 6; calcium channel, voltage-dependent, alpha 1E subunit; calcium channel, voltage-dependent, R type, alpha 1E subunit; calcium voltage-gated channel subunit alpha1 E; Cav2.3; EIEE69; gm139; voltage-dependent calcium channel alpha 1E subunit; Voltage-dependent R-type calcium channel subunit alpha-1E; voltage-gated calcium channel alpha 1E subunit; voltage-gated calcium channel alpha subunit Cav2.3; Voltage-gated calcium channel subunit alpha Cav2.3
Gene Symbols: CACNA1E
Molecular weight: 261,731 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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