SOD1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Mitochondrial; Nuclear receptor co-regulator; Oxidoreductase
Chromosomal Location of Human Ortholog: 11q11
Cellular Component:  axon cytoplasm; cytoplasm; cytoplasmic vesicle; cytosol; dendrite cytoplasm; dense core granule; extracellular region; extracellular space; lysosome; mitochondrial intermembrane space; mitochondrion; neuron projection; neuronal cell body; nucleoplasm; nucleus; peroxisome; protein-containing complex; secretory granule
Molecular Function:  chaperone binding; copper ion binding; enzyme binding; identical protein binding; protein phosphatase 2B binding; Rac GTPase binding; superoxide dismutase activity; zinc ion binding
Biological Process:  activation of MAPK activity; aging; anterograde axonal transport; auditory receptor cell stereocilium organization; cell aging; cellular iron ion homeostasis; cellular response to ATP; cellular response to cadmium ion; cellular response to oxidative stress; cellular response to potassium ion; embryo implantation; glutathione metabolic process; heart contraction; hydrogen peroxide biosynthetic process; locomotory behavior; muscle cell cellular homeostasis; myeloid cell homeostasis; negative regulation of apoptotic process; negative regulation of cholesterol biosynthetic process; negative regulation of inflammatory response; negative regulation of neuron apoptotic process; neurofilament cytoskeleton organization; ovarian follicle development; oxidation-reduction process; peripheral nervous system myelin maintenance; positive regulation of catalytic activity; positive regulation of cytokine production; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; positive regulation of phagocytosis; positive regulation of superoxide anion generation; reactive oxygen species metabolic process; regulation of blood pressure; regulation of GTPase activity; regulation of mitochondrial membrane potential; regulation of multicellular organism growth; regulation of protein kinase activity; relaxation of vascular smooth muscle; removal of superoxide radicals; response to amphetamine; response to antibiotic; response to antipsychotic drug; response to axon injury; response to carbon monoxide; response to copper ion; response to drug; response to ethanol; response to heat; response to hydrogen peroxide; response to nutrient levels; response to organic substance; response to oxidative stress; response to reactive oxygen species; response to superoxide; retina homeostasis; retrograde axonal transport; sensory perception of sound; spermatogenesis; superoxide anion generation; superoxide metabolic process; transmission of nerve impulse
Reference #:  P07632 (UniProtKB)
Alt. Names/Synonyms: CuZnSOD; Sod1; superoxide dismutase 1, soluble; Superoxide dismutase [Cu-Zn]
Gene Symbols: Sod1
Molecular weight: 15,912 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA