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Catalase
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Belongs to the catalase family. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase |
| Chromosomal Location of rat Ortholog: 3q32 |
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Cellular Component:
catalase complex; cytoplasm; extracellular space; intracellular membrane-bounded organelle; mitochondrion; peroxisomal membrane; peroxisome; protein-containing complex
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Molecular Function:
aminoacylase activity; antioxidant activity; catalase activity; enzyme binding; heme binding; identical protein binding; metal ion binding; NADP binding; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity
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Biological Process:
aerobic respiration; cellular detoxification of hydrogen peroxide; cellular oxidant detoxification; cellular response to growth factor stimulus; cholesterol metabolic process; hemoglobin metabolic process; hydrogen peroxide catabolic process; kidney development; negative regulation of apoptotic process; negative regulation of NF-kappaB transcription factor activity; positive regulation of cell division; positive regulation of NF-kappaB transcription factor activity; positive regulation of phosphatidylinositol 3-kinase signaling; response to activity; response to auditory stimulus; response to cadmium ion; response to estradiol; response to ethanol; response to fatty acid; response to hydrogen peroxide; response to hyperoxia; response to hypoxia; response to inactivity; response to insulin; response to L-ascorbic acid; response to lead ion; response to light intensity; response to oxidative stress; response to ozone; response to phenylpropanoid; response to reactive oxygen species; response to toxic substance; response to UV; response to vitamin A; response to vitamin E; response to xenobiotic stimulus; triglyceride metabolic process; ureteric bud development; UV protection
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Reference #:
P04762
(UniProtKB)
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Alt. Names/Synonyms: Cas1; Cat; Catalase; Cs-1; CS1; RATCAT01; RATCATL
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Gene Symbols: Cat
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Molecular weight:
59,757 Da
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Basal Isoelectric point:
7.07
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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