mGluR2 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Belongs to the G-protein coupled receptor 3 family. Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 9|9 F1
Cellular Component:  astrocyte projection; axon; cell projection; glutamatergic synapse; membrane; neuron projection; plasma membrane; presynapse; presynaptic membrane; synapse
Molecular Function:  calcium channel regulator activity; G protein-coupled receptor activity; group II metabotropic glutamate receptor activity; scaffold protein binding
Biological Process:  behavioral response to nicotine; cellular response to stress; G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; gene expression; glutamate secretion; intracellular glutamate homeostasis; long-term synaptic depression; presynaptic modulation of chemical synaptic transmission; regulation of dopamine secretion; regulation of glutamate secretion; regulation of protein kinase B signaling; regulation of response to drug; regulation of synaptic transmission, glutamatergic; response to cocaine; signal transduction
Reference #:  Q14BI2 (UniProtKB)
Alt. Names/Synonyms: 4930441L02Rik; G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; glutamate receptor, metabotropic 2; Gprc; Gprc1b; Grm2; Metabotropic glutamate receptor 2; mGlu; mGluR2; mGluR7
Gene Symbols: Grm2
Molecular weight: 95,887 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein