NEK6 Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Ubiquitous, with highest expression in heart and skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; NEK family; NEK6 subfamily; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 9q33.3
Cellular Component:  centriolar satellite; centrosome; cytoplasm; cytosol; microtubule; nuclear speck; nucleoplasm; nucleus; protein-containing complex; spindle pole
Molecular Function:  ATP binding; DNA-binding transcription factor binding; kinesin binding; magnesium ion binding; protein binding; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; transcription corepressor binding; ubiquitin protein ligase binding
Biological Process:  apoptotic process; cell division; chromosome segregation; mitotic nuclear membrane disassembly; mitotic spindle organization; peptidyl-serine phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of cellular senescence; regulation of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; spindle assembly
Reference #:  Q9HC98 (UniProtKB)
Alt. Names/Synonyms: NEK6; Never in mitosis A-related kinase 6; NIMA (never in mitosis gene a)-related kinase 6; NIMA related kinase 6; NimA-related protein kinase 6; Protein kinase SID6-1512; putative serine-threonine protein kinase; Serine/threonine-protein kinase Nek6; SID6-1512
Gene Symbols: NEK6
Molecular weight: 35,714 Da
Basal Isoelectric point: 8.26  Predict pI for various phosphorylation states
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