STX4 Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. May also play a role in docking of synaptic vesicles at presynaptic active zones. Belongs to the syntaxin family. Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 1q37
Cellular Component:  apical plasma membrane; basolateral plasma membrane; cell surface; cytoplasm; dendritic spine; endomembrane system; endosome; extracellular space; glutamatergic synapse; integral component of membrane; lamellipodium; lateral loop; membrane; myelin sheath adaxonal region; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane; postsynapse; presynaptic active zone membrane; presynaptic membrane; sarcolemma; SNARE complex; somatodendritic compartment; specific granule; storage vacuole; synapse; synaptic vesicle; trans-Golgi network
Molecular Function:  protein binding; Rab GTPase binding; SNAP receptor activity; SNARE binding; spectrin binding; sphingomyelin phosphodiesterase activator activity
Biological Process:  cellular response to interferon-gamma; exocytic insertion of neurotransmitter receptor to postsynaptic membrane; exocytosis; intracellular protein transport; intracellular transport; long-term synaptic potentiation; membrane fusion; organelle fusion; positive regulation of catalytic activity; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of eosinophil degranulation; positive regulation of immunoglobulin secretion; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of protein localization to cell surface; positive regulation of protein localization to plasma membrane; protein-containing complex assembly; regulation of exocytosis; regulation of extrinsic apoptotic signaling pathway via death domain receptors; response to hydroperoxide; SNARE complex assembly; synaptic vesicle docking; synaptic vesicle fusion to presynaptic active zone membrane; vesicle docking; vesicle fusion; vesicle-mediated transport in synapse
Reference #:  Q08850 (UniProtKB)
Alt. Names/Synonyms: Stx4; Stx4a; syntaxin 4; syntaxin 4A (placental); Syntaxin-4
Gene Symbols: Stx4
Molecular weight: 34,209 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene