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STX4
Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. May also play a role in docking of synaptic vesicles at presynaptic active zones. Belongs to the syntaxin family. Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Vesicle |
| Chromosomal Location of rat Ortholog: 1q37 |
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Cellular Component:
apical plasma membrane; basolateral plasma membrane; cell surface; cytoplasm; dendritic spine; endomembrane system; endosome; extracellular space; glutamatergic synapse; lamellipodium; lateral loop; membrane; myelin sheath adaxonal region; neuron projection membrane; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane; postsynapse; postsynaptic membrane; presynapse; sarcolemma; Schaffer collateral - CA1 synapse; SNARE complex; somatodendritic compartment; specific granule; storage vacuole; synapse; trans-Golgi network
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Molecular Function:
protein binding; small GTPase binding; SNAP receptor activity; SNARE binding; spectrin binding; sphingomyelin phosphodiesterase activator activity
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Biological Process:
cellular response to oxidative stress; cellular response to type II interferon; cornified envelope assembly; exocytic insertion of neurotransmitter receptor to postsynaptic membrane; exocytosis; intracellular protein transport; intracellular transport; long-term synaptic potentiation; membrane fusion; organelle fusion; positive regulation of catalytic activity; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of chemotaxis; positive regulation of eosinophil degranulation; positive regulation of immunoglobulin production; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of protein localization to cell surface; positive regulation of protein localization to plasma membrane; protein localization to cell surface; protein-containing complex assembly; regulation of exocytosis; regulation of extrinsic apoptotic signaling pathway via death domain receptors; SNARE complex assembly; synaptic vesicle docking; vesicle docking; vesicle fusion; vesicle-mediated transport; vesicle-mediated transport in synapse
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Reference #:
Q08850
(UniProtKB)
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Alt. Names/Synonyms: Stx4; Stx4a; syntaxin 4; syntaxin 4A (placental); Syntaxin-4
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Gene Symbols: Stx4
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Molecular weight:
34,195 Da
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Basal Isoelectric point:
5.84
Predict pI for various phosphorylation states
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