RAP1GAP2 GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of Human Ortholog: 11|11 B5
Cellular Component:  centrosome; cytoplasm; cytosol; neuron projection; nuclear membrane; plasma membrane
Molecular Function:  GTPase activator activity
Biological Process:  negative regulation of neuron projection development; regulation of cell size; regulation of small GTPase mediated signal transduction
Reference #:  Q5SVL6 (UniProtKB)
Alt. Names/Synonyms: AU067654; Garnl4; Gm1561; GTPase activating RANGAP domain-like 4; GTPase-activating Rap/Ran-GAP domain-like protein 4; Kiaa1039; MGC130388; mKIAA1039; OTTMUSP00000006465; RAP1 GTPase activating protein 2; Rap1 GTPase-activating protein 2; Rap1ga2; Rap1GAP2; RPGP2
Gene Symbols: Rap1gap2
Molecular weight: 78,254 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene