VAMP2 a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 10q24
Cellular Component:  cell junction; clathrin-coated vesicle; cytoplasmic vesicle; cytoplasmic vesicle membrane; integral to synaptic vesicle membrane; intracellular membrane-bound organelle; intracellular organelle; membrane; neuron projection; neuron projection terminus; perinuclear region of cytoplasm; plasma membrane; secretory granule; secretory granule membrane; SNARE complex; storage vacuole; synapse; synaptic vesicle; synaptic vesicle membrane; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex; trans-Golgi network; vesicle; voltage-gated potassium channel complex; zymogen granule membrane
Molecular Function:  calcium-dependent protein binding; calmodulin binding; identical protein binding; ion channel binding; myosin binding; phospholipid binding; protein binding; protein C-terminus binding; SNARE binding; syntaxin binding; syntaxin-1 binding
Biological Process:  calcium ion-dependent exocytosis; cellular response to insulin stimulus; eosinophil degranulation; exocytic insertion of neurotransmitter receptor to postsynaptic membrane; Golgi to plasma membrane protein transport; macromolecular complex assembly; natural killer cell degranulation; neutrophil degranulation; positive regulation of intracellular protein transport; protein transport; regulation of delayed rectifier potassium channel activity; regulation of exocytosis; response to glucose stimulus; synaptic vesicle exocytosis; vesicle-mediated transport
Reference #:  P63045 (UniProtKB)
Alt. Names/Synonyms: RATVAMPB; RATVAMPIR; SYB; Syb2; Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2); Synaptobrevin-2; VAMP-2; Vamp2; Vesicle-associated membrane protein (synaptobrevin 2); Vesicle-associated membrane protein 2
Gene Symbols: Vamp2
Molecular weight: 12,691 Da
Basal Isoelectric point: 7.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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VAMP2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene