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SNAP23
Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. Belongs to the SNAP-25 family. Ubiquitous. Highest levels where found in placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Vesicle |
| Chromosomal Location of mouse Ortholog: 2 60.37 cM|2 E5 |
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Cellular Component:
adherens junction; azurophil granule; cytoplasm; cytoplasmic vesicle; GABA-ergic synapse; glutamatergic synapse; membrane; mitochondrion; neuron projection; nucleoplasm; plasma membrane; postsynapse; SNARE complex; specific granule; synapse; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
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Molecular Function:
protein binding; SNAP receptor activity; syntaxin binding; syntaxin-1 binding
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Biological Process:
exocytic insertion of neurotransmitter receptor to postsynaptic membrane; exocytosis; histamine secretion by mast cell; membrane fusion; protein transport; protein-containing complex assembly; regulation of exocytosis; synaptic vesicle fusion to presynaptic active zone membrane; synaptic vesicle priming; vesicle-mediated transport; vesicle-mediated transport in synapse
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Reference #:
O09044
(UniProtKB)
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Alt. Names/Synonyms: 23kDa; AA408749; OTTMUSP00000016633; OTTMUSP00000016635; SNA; SNAP-23; Snap23; Sndt; SNP23; Synaptosomal-associated protein 23; synaptosomal-associated protein, 23kD; Synd; Syndet; Vesicle-membrane fusion protein SNAP-23
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Gene Symbols: Snap23
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Molecular weight:
23,261 Da
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Basal Isoelectric point:
4.88
Predict pI for various phosphorylation states
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