SNAP23 a member of the SNAP-25 family of SNARE proteins. Structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 3q35
Cellular Component:  azurophil granule; cell junction; cell-cell adherens junction; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; GABA-ergic synapse; glutamatergic synapse; nucleoplasm; plasma membrane; postsynapse; SNARE complex; specific granule
Molecular Function:  protein binding; SNAP receptor activity; syntaxin binding
Biological Process:  exocytic insertion of neurotransmitter receptor to postsynaptic membrane; exocytosis; histamine secretion by mast cell; membrane fusion; protein transport; protein-containing complex assembly; regulation of exocytosis; synaptic vesicle fusion to presynaptic active zone membrane; synaptic vesicle priming; vesicle fusion; vesicle-mediated transport; vesicle-mediated transport in synapse
Reference #:  O70377 (UniProtKB)
Alt. Names/Synonyms: SNAP-23; Snap23; SNP23; Synaptosomal-associated protein 23; synaptosomal-associated protein 23 kD; synaptosomal-associated protein, 23 kD; Vesicle-membrane fusion protein SNAP-23
Gene Symbols: Snap23
Molecular weight: 23,235 Da
Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene