AA-NAT Catalyzes the N-acetylation of serotonin into N- acetylserotonin. Controls the night/day rhythm of melatonin production in the pineal gland. Has a relative affinity for hydroxylated versus non-hydroxylated arylalkylamines. Belongs to the acetyltransferase family. AANAT subfamily. Monomer. Interacts with YWHAZ; the interaction requires phosphorylation on Thr-31, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind, via the phosphorylated Ser-205 site, the other YWHAZ monomer with similar effect. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; Amino Acid Metabolism - tryptophan; EC 2.3.1.87
Cellular Component: 
Reference #:  Q29495 (UniProtKB)
Alt. Names/Synonyms: AANAT; aralkylamine N-acetyltransferase; serotonin acetylase; Serotonin N-acetyltransferase; SNAT
Gene Symbols: AANAT
Molecular weight: 23,077 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
Select Structure to View Below

AA-NAT

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene