|
PLCL1
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Phospholipase |
| Chromosomal Location of rat Ortholog: 9q31 |
|
Cellular Component:
cytoplasm
|
|
Molecular Function:
GABA receptor binding; phosphatidylinositol phospholipase C activity
|
|
Biological Process:
gamma-aminobutyric acid signaling pathway; intracellular signal transduction; lipid catabolic process; lipid metabolic process; negative regulation of cold-induced thermogenesis; positive regulation of receptor binding; regulation of synaptic transmission, GABAergic
|
|
Reference #:
Q62688
(UniProtKB)
|
|
Alt. Names/Synonyms: 130kDa-Ins(1,4,5)P3 binding protein; Inactive phospholipase C-like protein 1; p130; phospholipase C-like 1; Phospholipase C-related but catalytically inactive protein; PLC-L1; Plcl1; PRIP1
|
|
Gene Symbols: Plcl1
|
|
Molecular weight:
122,772 Da
|
|
Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
|
|
CST Pathways:
ErbB/HER Signaling
|
