PLCL1
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Phospholipase |
Chromosomal Location of rat Ortholog: 9q31 |
Cellular Component:
cytoplasm
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Molecular Function:
GABA receptor binding; phosphatidylinositol phospholipase C activity
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Biological Process:
gamma-aminobutyric acid signaling pathway; intracellular signal transduction; lipid catabolic process; lipid metabolic process; negative regulation of cold-induced thermogenesis; positive regulation of receptor binding; regulation of synaptic transmission, GABAergic
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Reference #:
Q62688
(UniProtKB)
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Alt. Names/Synonyms: 130kDa-Ins(1,4,5)P3 binding protein; Inactive phospholipase C-like protein 1; p130; phospholipase C-like 1; Phospholipase C-related but catalytically inactive protein; PLC-L1; Plcl1; PRIP1
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Gene Symbols: Plcl1
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Molecular weight:
122,772 Da
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Basal Isoelectric point:
5.47
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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