PLCL1 a protein closely related to phospholipase C-d1 (PLC-d1) but catalytically inactive. First identified as a novel inositol 1,4,5-trisphosphate binding protein. Has a number of binding partners including protein phosphatase (PP1 and 2A), GABA(A) receptor associated protein, and the beta subunits of GABA(A) receptors, in addition to inositol 1,4,5-trisphosphate. Plays an important role in controlling the dynamics of GABA(A) receptor phosphorylation through PP1 binding and, therefore, the efficacy of synaptic inhibition mediated by these receptors. Note: This description may include information from UniProtKB.
Protein type: Phospholipase
Chromosomal Location of Human Ortholog: 2q33.1
Cellular Component:  cytoplasm; plasma membrane
Molecular Function:  GABA receptor binding; inositol 1,4,5 trisphosphate binding; phosphatidylinositol phospholipase C activity; phospholipase C activity
Biological Process:  gamma-aminobutyric acid signaling pathway; intracellular signal transduction; lipid metabolic process; negative regulation of cold-induced thermogenesis; positive regulation of receptor binding; regulation of peptidyl-serine phosphorylation; regulation of synaptic transmission, GABAergic
Reference #:  Q15111 (UniProtKB)
Alt. Names/Synonyms: Inactive phospholipase C-like protein 1; MGC126580; MGC138190; phospholipase C related, but catalytically inactive protein; phospholipase C, epsilon; Phospholipase C-deleted in lung carcinoma; phospholipase C-like 1; Phospholipase C-related but catalytically inactive protein; PLC-L1; PLCE; PLCL; PLCL1; PLDL1; PRIP
Gene Symbols: PLCL1
Molecular weight: 122,728 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below

PLCL1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene