G-beta 4 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Belongs to the WD repeat G protein beta family. Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves. Note: This description may include information from UniProtKB.
Protein type: G protein, heterotrimeric; G protein, heterotrimeric beta; Membrane protein, peripheral
Chromosomal Location of human Ortholog: 3q26.33
Cellular Component:  cell body; cytoplasm; cytosol; heterotrimeric G-protein complex
Molecular Function:  protein binding; protein-containing complex binding; signaling receptor complex adaptor activity
Biological Process:  G protein-coupled receptor signaling pathway
Disease: Charcot-marie-tooth Disease, Dominant Intermediate F
Reference #:  Q9HAV0 (UniProtKB)
Alt. Names/Synonyms: CMTD1F; G protein beta-4 subunit; G protein subunit beta 4; G-beta 4; GBB4; GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4; guanine nucleotide binding protein beta subunit 4; Guanine nucleotide-binding protein subunit beta-4; Transducin beta chain 4
Gene Symbols: GNB4
Molecular weight: 37,567 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
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G-beta 4

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene