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G-beta 4
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Belongs to the WD repeat G protein beta family. Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves. Note: This description may include information from UniProtKB.
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| Protein type: G protein, heterotrimeric; G protein, heterotrimeric beta; Membrane protein, peripheral |
| Chromosomal Location of human Ortholog: 3q26.33 |
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Cellular Component:
cell body; cytoplasm; cytosol; heterotrimeric G-protein complex
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Molecular Function:
protein binding; protein-containing complex binding; signaling receptor complex adaptor activity
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Biological Process:
G protein-coupled receptor signaling pathway
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Disease: Charcot-marie-tooth Disease, Dominant Intermediate F
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Reference #:
Q9HAV0
(UniProtKB)
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Alt. Names/Synonyms: CMTD1F; G protein beta-4 subunit; G protein subunit beta 4; G-beta 4; GBB4; GNB4; guanine nucleotide binding protein (G protein), beta polypeptide 4; guanine nucleotide binding protein beta subunit 4; Guanine nucleotide-binding protein subunit beta-4; Transducin beta chain 4
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Gene Symbols: GNB4
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Molecular weight:
37,567 Da
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Basal Isoelectric point:
5.59
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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Parkinson's Disease
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Phospholipase Signaling
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PI3K/Akt Signaling
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SAPK/JNK Signaling Cascades
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