G-beta 4 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Belongs to the WD repeat G protein beta family. Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves. Note: This description may include information from UniProtKB.
Protein type: G protein, heterotrimeric; G protein, heterotrimeric beta; Membrane protein, peripheral
Chromosomal Location of Human Ortholog: 3|3 A3
Cellular Component:  cell body; heterotrimeric G-protein complex
Molecular Function:  GTPase activity; protein-containing complex binding
Biological Process:  G protein-coupled receptor signaling pathway; signal transduction
Reference #:  P29387 (UniProtKB)
Alt. Names/Synonyms: 6720453A21Rik; G(beta)4; GBB4; Gnb4; guanine nucleotide binding protein (G protein), beta 4; guanine nucleotide binding protein, beta 4; Guanine nucleotide-binding protein subunit beta-4; OTTMUSP00000017672; OTTMUSP00000017673; Transducin beta chain 4
Gene Symbols: Gnb4
Molecular weight: 37,379 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
Select Structure to View Below

G-beta 4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene