G-beta 3 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Belongs to the WD repeat G protein beta family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric beta
Chromosomal Location of human Ortholog: 12p13.31
Cellular Component:  cell body; cytoplasm; cytosol; dendrite; heterotrimeric G-protein complex; plasma membrane
Molecular Function:  GTPase activity; GTPase binding; protein binding; signaling receptor complex adaptor activity; spectrin binding
Biological Process:  cell volume homeostasis; G protein-coupled receptor signaling pathway; regulation of blood pressure; regulation of cholesterol metabolic process; regulation of fat cell differentiation; regulation of feeding behavior; regulation of gene expression; regulation of glucose metabolic process; regulation of hormone metabolic process; regulation of locomotion involved in locomotory behavior; regulation of phospholipid metabolic process; regulation of triglyceride metabolic process
Disease: Hypertension, Essential; Night Blindness, Congenital Stationary, Type 1h
Reference #:  P16520 (UniProtKB)
Alt. Names/Synonyms: CSNB1H; G protein subunit beta 3; G protein, beta-3 subunit; G-beta 3; GBB3; GNB3; GTP-binding regulatory protein beta-3 chain; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; hypertension associated protein; Transducin beta chain 3
Gene Symbols: GNB3
Molecular weight: 37,221 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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G-beta 3
Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein