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TUBB4
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. Major isotype in brain, where it represents 46% of all beta-tubulins. In the brain, highest expression levels in the cerebellum, followed by putamen and white matter. Moderate levels in testis. Very low levels, if any, in other tissues. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 19p13.3 |
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Cellular Component:
axoneme; cytoplasm; cytosol; intercellular bridge; internode region of axon; microtubule; microtubule cytoskeleton; mitotic spindle; myelin sheath; neuronal cell body
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Molecular Function:
calcium ion binding; GTP binding; GTPase activity; protein binding; structural constituent of cytoskeleton
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Biological Process:
microtubule cytoskeleton organization; mitotic cell cycle; negative regulation of microtubule polymerization
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Disease: Dystonia 4, Torsion, Autosomal Dominant; Leukodystrophy, Hypomyelinating, 6
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Reference #:
P04350
(UniProtKB)
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Alt. Names/Synonyms: beta-5; dystonia 4, torsion (autosomal dominant); DYT4; TBB4; TBB4A; TUBB4; TUBB4A; TUBB5; Tubulin 5 beta; tubulin beta 4A class IVa; Tubulin beta-4 chain; Tubulin beta-4A chain; tubulin, beta 4; tubulin, beta, 5
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Gene Symbols: TUBB4A
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Molecular weight:
49,586 Da
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Basal Isoelectric point:
4.78
Predict pI for various phosphorylation states
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