TUBB4 Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. Major isotype in brain, where it represents 46% of all beta-tubulins. In the brain, highest expression levels in the cerebellum, followed by putamen and white matter. Moderate levels in testis. Very low levels, if any, in other tissues. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  axoneme; cytosol; internode region of axon; microtubule; myelin sheath; neuronal cell body
Molecular Function:  calcium ion binding; GTPase activity; protein binding
Biological Process:  ciliary basal body-plasma membrane docking; G2/M transition of mitotic cell cycle; negative regulation of microtubule polymerization; regulation of G2/M transition of mitotic cell cycle
Disease: Dystonia 4, Torsion, Autosomal Dominant; Leukodystrophy, Hypomyelinating, 6
Reference #:  P04350 (UniProtKB)
Alt. Names/Synonyms: beta-5; dystonia 4, torsion (autosomal dominant); DYT4; TBB4; TBB4A; TUBB4; TUBB4A; TUBB5; Tubulin 5 beta; tubulin beta 4A class IVa; Tubulin beta-4 chain; Tubulin beta-4A chain; tubulin, beta 4; tubulin, beta, 5
Gene Symbols: TUBB4A
Molecular weight: 49,586 Da
Basal Isoelectric point: 4.78  Predict pI for various phosphorylation states
Select Structure to View Below

TUBB4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB