G-alpha 12 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade. Belongs to the G-alpha family. G(12) subfamily. 3 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(12)
Chromosomal Location of human Ortholog: 7p22.3-p22.2
Cellular Component:  cytoplasm; lateral plasma membrane; plasma membrane
Molecular Function:  GTP binding; metal ion binding; protein binding
Biological Process:  blood coagulation; cell differentiation; embryonic digit morphogenesis; G protein-coupled receptor signaling pathway; in utero embryonic development; platelet activation; regulation of cell shape; regulation of fibroblast migration; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of TOR signaling; response to drug
Reference #:  Q03113 (UniProtKB)
Alt. Names/Synonyms: G alpha-12; G protein subunit alpha 12; G-alpha 12; G-protein subunit alpha-12; gep; GNA12; guanine nucleotide binding protein (G protein) alpha 12; Guanine nucleotide-binding protein subunit alpha-12; MGC104623; MGC99644; NNX3; RMP; WUGSC:H_GS165O14.2
Gene Symbols: GNA12
Molecular weight: 44,279 Da
Basal Isoelectric point: 9.84  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  SAPK/JNK Signaling Cascades
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G-alpha 12

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB