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G-alpha 12
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade. Belongs to the G-alpha family. G(12) subfamily. 3 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(12) |
| Chromosomal Location of mouse Ortholog: 5 G2|5 79.3 cM |
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Cellular Component:
brush border membrane; cytoplasm; heterotrimeric G-protein complex; lateral plasma membrane; membrane; neuron projection; neuronal cell body; plasma membrane
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Molecular Function:
D5 dopamine receptor binding; G protein-coupled receptor binding; G-protein beta/gamma-subunit complex binding; GTP binding; GTPase activity; guanyl nucleotide binding; metal ion binding; nucleotide binding; protein phosphatase 2A binding; protein phosphatase regulator activity
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Biological Process:
adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cell differentiation; embryonic digit morphogenesis; G protein-coupled receptor signaling pathway; in utero embryonic development; intracellular signal transduction; negative regulation of vascular associated smooth muscle cell migration; negative regulation of vascular associated smooth muscle cell proliferation; positive regulation of phosphoprotein phosphatase activity; regulation of blood pressure; regulation of cell shape; regulation of fibroblast migration; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of TOR signaling; Rho protein signal transduction; signal transduction
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Reference #:
P27600
(UniProtKB)
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Alt. Names/Synonyms: AI414047; AI504261; G alpha-12; G-alpha 12; G-protein subunit alpha-12; Galp; Galpha12; Gna-12; Gna12; guanine nucleotide binding protein, alpha 12; Guanine nucleotide-binding protein subunit alpha-12; MGC130498; OTTMUSP00000029883
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Gene Symbols: Gna12
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Molecular weight:
44,095 Da
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Basal Isoelectric point:
9.84
Predict pI for various phosphorylation states
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CST Pathways:
Microtubule Dynamics
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Phospholipase Signaling
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PI3K/Akt Signaling
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SAPK/JNK Signaling Cascades
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