RAB3A Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells. Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9. Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1. Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT. Belongs to the small GTPase superfamily. Rab family. Specifically expressed in brain. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 8 B3.3|8 34.15 cM
Cellular Component:  acrosomal vesicle; anchored component of synaptic vesicle membrane; axon; cytosol; endosome; intracellular organelle; membrane; perinuclear region of cytoplasm; plasma membrane; presynaptic active zone; protein-containing complex; secretory granule; synaptic vesicle; terminal bouton; vesicle
Molecular Function:  ATPase activator activity; ATPase binding; GDP-dissociation inhibitor binding; GTP binding; GTP-dependent protein binding; GTPase activity; myosin V binding; nucleotide binding; protein binding; protein C-terminus binding
Biological Process:  acrosomal vesicle exocytosis; axonogenesis; calcium ion regulated exocytosis; evoked neurotransmitter secretion; exocytosis; intracellular protein transport; lung development; lysosome localization; maintenance of presynaptic active zone structure; mitochondrion organization; neuromuscular synaptic transmission; plasma membrane repair; positive regulation of regulated secretory pathway; post-embryonic development; protein localization to plasma membrane; protein secretion; protein transport; Rab protein signal transduction; regulated exocytosis; regulation of exocytosis; regulation of long-term synaptic potentiation; regulation of plasma membrane repair; regulation of short-term neuronal synaptic plasticity; regulation of synaptic vesicle exocytosis; regulation of synaptic vesicle fusion to presynaptic active zone membrane; regulation of synaptic vesicle priming; respiratory system process; response to electrical stimulus; sensory perception of touch; synaptic vesicle clustering; synaptic vesicle exocytosis; synaptic vesicle maturation; synaptic vesicle recycling; synaptic vesicle transport; vesicle docking involved in exocytosis
Reference #:  P63011 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000018415; OTTMUSP00000018416; OTTMUSP00000018420; OTTMUSP00000025402; Rab3a; RAB3A, member RAS oncogene family; Ras-related protein Rab-3A
Gene Symbols: Rab3a
Molecular weight: 24,970 Da
Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene