RAB3A Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3. Specifically expressed in brain. Belongs to the small GTPase superfamily. Rab family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component:  acrosomal vesicle; axon; clathrin-sculpted acetylcholine transport vesicle membrane; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; clathrin-sculpted glutamate transport vesicle membrane; clathrin-sculpted monoamine transport vesicle membrane; cytosol; lysosome; perinuclear region of cytoplasm; plasma membrane; presynaptic active zone; protein-containing complex; secretory granule membrane; synaptic vesicle; terminal bouton
Molecular Function:  ATPase activator activity; ATPase binding; GDP-dissociation inhibitor binding; GTP binding; GTP-dependent protein binding; GTPase activity; myosin V binding; protein binding; protein C-terminus binding
Biological Process:  acrosomal vesicle exocytosis; constitutive secretory pathway; evoked neurotransmitter secretion; exocytosis; glutamate secretion; lung development; lysosome localization; mitochondrion organization; neuromuscular synaptic transmission; neurotransmitter secretion; neutrophil degranulation; plasma membrane repair; positive regulation of ATPase activity; positive regulation of exocytosis; positive regulation of regulated secretory pathway; post-embryonic development; post-translational protein modification; regulated exocytosis; regulation of plasma membrane repair; regulation of short-term neuronal synaptic plasticity; regulation of synaptic vesicle fusion to presynaptic active zone membrane; regulation of synaptic vesicle priming; respiratory system process; response to electrical stimulus; sensory perception of touch; synaptic vesicle clustering; synaptic vesicle exocytosis; synaptic vesicle maturation; synaptic vesicle recycling
Reference #:  P20336 (UniProtKB)
Alt. Names/Synonyms: RAB3A; RAB3A, member RAS oncogene family; RAS-associated protein RAB3A; Ras-related protein Rab-3A
Gene Symbols: RAB3A
Molecular weight: 24,984 Da
Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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