RAB3A Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells. Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9. Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1. Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT. Belongs to the small GTPase superfamily. Rab family. Specifically expressed in brain. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component:  acrosomal vesicle; axon; clathrin-sculpted acetylcholine transport vesicle membrane; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; clathrin-sculpted glutamate transport vesicle membrane; clathrin-sculpted monoamine transport vesicle membrane; cytosol; lysosome; perinuclear region of cytoplasm; plasma membrane; presynaptic active zone; protein-containing complex; secretory granule membrane; synaptic vesicle; terminal bouton
Molecular Function:  ATPase activator activity; ATPase binding; GDP-dissociation inhibitor binding; GTP binding; GTP-dependent protein binding; GTPase activity; myosin V binding; protein binding; protein C-terminus binding
Biological Process:  acrosomal vesicle exocytosis; constitutive secretory pathway; evoked neurotransmitter secretion; exocytosis; glutamate secretion; lung development; lysosome localization; mitochondrion organization; neuromuscular synaptic transmission; neurotransmitter secretion; neutrophil degranulation; plasma membrane repair; positive regulation of ATPase activity; positive regulation of exocytosis; positive regulation of regulated secretory pathway; post-embryonic development; post-translational protein modification; regulated exocytosis; regulation of plasma membrane repair; regulation of short-term neuronal synaptic plasticity; regulation of synaptic vesicle fusion to presynaptic active zone membrane; regulation of synaptic vesicle priming; respiratory system process; response to electrical stimulus; sensory perception of touch; synaptic vesicle clustering; synaptic vesicle exocytosis; synaptic vesicle maturation; synaptic vesicle recycling
Reference #:  P20336 (UniProtKB)
Alt. Names/Synonyms: RAB3A; RAB3A, member RAS oncogene family; RAS-associated protein RAB3A; Ras-related protein Rab-3A
Gene Symbols: RAB3A
Molecular weight: 24,984 Da
Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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