PEDF Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Belongs to the serpin family. Retinal pigment epithelial cells and blood plasma. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 17p13.3
Cellular Component:  axon hillock; basement membrane; extracellular region; melanosome; perinuclear region of cytoplasm
Molecular Function:  protein binding
Biological Process:  aging; cellular response to cobalt ion; cellular response to dexamethasone stimulus; cellular response to glucose stimulus; cellular response to retinoic acid; kidney development; negative regulation of angiogenesis; negative regulation of endothelial cell migration; negative regulation of epithelial cell proliferation involved in prostate gland development; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of neuron death; ovulation cycle; positive regulation of neurogenesis; positive regulation of neuron projection development; response to acidic pH; response to arsenic-containing substance; retina development in camera-type eye; short-term memory
Disease: Osteogenesis Imperfecta, Type Vi
Reference #:  P36955 (UniProtKB)
Alt. Names/Synonyms: alpha-2 antiplasmin; Cell proliferation-inducing gene 35 protein; EPC-1; OI12; OI6; PEDF; PIG35; Pigment epithelium-derived factor; proliferation-inducing protein 35; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Serpin F1; serpin family F member 1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; SERPINF1; testis tissue sperm-binding protein Li 70n
Gene Symbols: SERPINF1
Molecular weight: 46,312 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB