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PEDF
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Belongs to the serpin family. Retinal pigment epithelial cells and blood plasma. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 17p13.3 |
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Cellular Component:
axon hillock; basement membrane; extracellular region; extracellular space; melanosome; perinuclear region of cytoplasm
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Molecular Function:
protein binding; serine-type endopeptidase inhibitor activity
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Biological Process:
cellular response to cobalt ion; cellular response to dexamethasone stimulus; cellular response to glucose stimulus; cellular response to retinoic acid; epithelial cell proliferation involved in prostate gland development; kidney development; negative regulation of angiogenesis; negative regulation of endopeptidase activity; negative regulation of endothelial cell migration; negative regulation of epithelial cell proliferation involved in prostate gland development; negative regulation of gene expression; negative regulation of neuron death; ovulation cycle; positive regulation of neurogenesis; positive regulation of neuron projection development; response to acidic pH; response to arsenic-containing substance; response to peptide; retina development in camera-type eye; short-term memory
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Disease: Osteogenesis Imperfecta, Type Vi
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Reference #:
P36955
(UniProtKB)
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Alt. Names/Synonyms: alpha-2 antiplasmin; Cell proliferation-inducing gene 35 protein; EPC-1; OI12; OI6; PEDF; PIG35; Pigment epithelium-derived factor; proliferation-inducing protein 35; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Serpin F1; serpin family F member 1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; SERPINF1; testis tissue sperm-binding protein Li 70n
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Gene Symbols: SERPINF1
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Molecular weight:
46,312 Da
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Basal Isoelectric point:
5.97
Predict pI for various phosphorylation states
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