NDR1 Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; NDR family; NDR subfamily; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 6p21.31
Cellular Component:  cytoplasm; cytosol; glutamatergic synapse; nucleus
Molecular Function:  ATP binding; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  intracellular signal transduction; negative regulation of MAP kinase activity; peptidyl-serine phosphorylation; postsynapse organization; protein modification process; protein phosphorylation
Reference #:  Q15208 (UniProtKB)
Alt. Names/Synonyms: NDR; Ndr Ser/Thr kinase-like protein; NDR1; NDR1 protein kinase; nuclear Dbf2-related 1; Nuclear Dbf2-related kinase 1; serine threonine protein kinase; serine/threonine kinase 38; Serine/threonine-protein kinase 38; STK38
Gene Symbols: STK38
Molecular weight: 54,190 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Substrate Sequence Logo
Open Substrate Page

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein