NDR1 is an AGC kinase of the NDR family. An apparent upstream regulator of Myc activity in human B-cell lymphoma. Mediates apoptosis downstream of the tumor suppressor proteins RASSF1A and MST1. Reduced expression of NDR1 results in defective apoptotic responses and a predisposition to develop T cell lymphoma in mice. Activated by binding of S100B which releases autoinhibitory N-lobe interactions. Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.1; Kinase, protein; NDR family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 6p21.31
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  ATP binding; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein serine/threonine kinase activity
Biological Process:  cellular protein modification process; intracellular signal transduction; negative regulation of MAP kinase activity; protein phosphorylation
Reference #:  Q15208 (UniProtKB)
Alt. Names/Synonyms: NDR; Ndr Ser/Thr kinase-like protein; NDR1; NDR1 protein kinase; nuclear Dbf2-related 1; Nuclear Dbf2-related kinase 1; serine threonine protein kinase; serine/threonine kinase 38; Serine/threonine-protein kinase 38; STK38
Gene Symbols: STK38
Molecular weight: 54,190 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
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NDR1

Protein Structure Not Found.


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