AHR Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription. Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6q16
Cellular Component:  aryl hydrocarbon receptor complex; cytoplasm; cytosol; nucleus; protein-containing complex
Molecular Function:  aryl hydrocarbon receptor binding; chaperone binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; enhancer binding; Hsp90 protein binding; nuclear receptor activity; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; TBP-class protein binding; TFIID-class transcription factor complex binding; toxic substance binding; transcription coactivator binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process:  apoptotic process; B cell homeostasis; blood circulation; blood vessel development; blood vessel morphogenesis; blood vessel remodeling; branching involved in blood vessel morphogenesis; camera-type eye development; cAMP-mediated signaling; cardiac left ventricle morphogenesis; cell morphogenesis; cellular response to 2,3,7,8-tetrachlorodibenzodioxine; cellular response to 3-methylcholanthrene; cellular response to cAMP; cellular response to forskolin; cellular response to glucocorticoid stimulus; circadian regulation of gene expression; circumferential growth involved in left ventricle morphogenesis; common bile duct development; embryonic hemopoiesis; gland development; glomerulus morphogenesis; immune system process; intracellular receptor signaling pathway; kidney morphogenesis; liver development; lymphocyte homeostasis; negative regulation of alkaline phosphatase activity; negative regulation of calcium ion transmembrane transport; negative regulation of DNA biosynthetic process; negative regulation of necrotic cell death; negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; negative regulation of systemic arterial blood pressure; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of vasoconstriction; ovarian follicle development; positive regulation of cell size; positive regulation of growth rate; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; post-embryonic hemopoiesis; prostate gland development; regulation of B cell proliferation; regulation of blood vessel size; regulation of cell cycle; regulation of gene expression; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; reproductive structure development; response to estradiol; response to organic cyclic compound; response to toxic substance; response to xenobiotic stimulus; smooth muscle tissue development; spleen development; T cell homeostasis; transcription by RNA polymerase II; venous blood vessel development; xenobiotic metabolic process
Reference #:  P41738 (UniProtKB)
Alt. Names/Synonyms: Ah receptor; AhR; Aryl hydrocarbon receptor
Gene Symbols: Ahr
Molecular weight: 96,227 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene