MAIR-I Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6. Belongs to the CD300 family. Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11 E2|11 80.54 cM
Cellular Component:  integral component of membrane; membrane; plasma membrane
Molecular Function:  phosphatase binding; phosphatidylethanolamine binding; phosphatidylserine binding; protein binding; signaling receptor activity
Biological Process:  immune system process; negative regulation of activation of Janus kinase activity; negative regulation of B cell proliferation; negative regulation of B cell receptor signaling pathway; negative regulation of eosinophil activation; negative regulation of eosinophil migration; negative regulation of fibroblast proliferation; negative regulation of MAP kinase activity; negative regulation of mast cell activation involved in immune response; negative regulation of mast cell degranulation; negative regulation of MyD88-dependent toll-like receptor signaling pathway; negative regulation of neutrophil activation; negative regulation of NK T cell activation; negative regulation of phagocytosis, engulfment; negative regulation of serotonin secretion; positive regulation of phosphoprotein phosphatase activity; receptor-mediated endocytosis; regulation of T cell receptor signaling pathway; serotonin secretion by mast cell
Reference #:  Q6SJQ0 (UniProtKB)
Alt. Names/Synonyms: B230315M08Rik; CD300 antigen-like family member A; Cd300a; CD300A antigen; CD300A molecule; Clm; CLM-8; Clm8; CMRF35-like molecule 8; Leukocyte mono-Ig-like receptor 1; Lmir1; MAIR-1; MAIR-I; MAIR-Ia; Mast cell-derived paired immunoglobulin-like receptor 1; Mcpir1; MMAC; MMAC8; Myeloid-associated immunoglobulin-like receptor 1; OTTMUSP00000003633; Pigr4; polymeric immunoglobulin receptor 4
Gene Symbols: Cd300a
Molecular weight: 35,629 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene