ARAP3
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Molecular Function: GTPase activator activity; metal ion binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding
Biological Process: cytoskeleton organization; positive regulation of GTPase activity; signal transduction; vesicle-mediated transport
Alt. Names/Synonyms: ARAP3; Arf and Rho GAP adapter protein 3; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3; centaurin, delta 3; Centaurin-delta-3; CENTD3; Cnt-d3; DRAG1; FLJ21065; phosphoinositide binding protein; PtdIns(3,4,5)P3-binding protein
