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NG2
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. Detected only in malignant melanoma cells. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 15q24.2 |
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Cellular Component:
apical plasma membrane; cell surface; extracellular region; Golgi lumen; lamellipodium membrane; lysosomal lumen; nucleoplasm; plasma membrane; ruffle
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Molecular Function:
coreceptor activity; protein kinase binding
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Biological Process:
angiogenesis; glial cell migration; intracellular signal transduction; platelet-derived growth factor receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of peptidyl-tyrosine phosphorylation; ruffle assembly; substrate-dependent cell migration; tissue remodeling
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Reference #:
Q6UVK1
(UniProtKB)
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Alt. Names/Synonyms: Chondroitin sulfate proteoglycan 4; chondroitin sulfate proteoglycan 4 (melanoma-associated); Chondroitin sulfate proteoglycan NG2; CSPG4; CSPG4A; HMW-MAA; MCSP; MCSPG; MEL-CSPG; Melanoma chondroitin sulfate proteoglycan; Melanoma-associated chondroitin sulfate proteoglycan; MSK16; NG2
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Gene Symbols: CSPG4
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Molecular weight:
250,537 Da
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Basal Isoelectric point:
5.27
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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