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SLC6A12
Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily. Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of mouse Ortholog: 6|6 F1 |
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Cellular Component:
basolateral plasma membrane; membrane; plasma membrane
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Molecular Function:
gamma-aminobutyric acid:sodium:chloride symporter activity; monocarboxylic acid transmembrane transporter activity; symporter activity
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Biological Process:
gamma-aminobutyric acid transport; glycine betaine transport; intracellular water homeostasis; monocarboxylic acid transport; neurotransmitter transport; sodium ion transmembrane transport
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Reference #:
P31651
(UniProtKB)
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Alt. Names/Synonyms: BGT1; Gabt; Gabt2; gamma-aminobutyric acid (GABA-A) transporter 2; GAT-2; Gat2; Na(+)/Cl(-) betaine/GABA transporter; S6A12; Slc6a12; Sodium- and chloride-dependent betaine transporter; Sodium- and chloride-dependent GABA transporter 2; solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12; Solute carrier family 6 member 12; Transporter
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Gene Symbols: Slc6a12
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Molecular weight:
69,614 Da
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Basal Isoelectric point:
6.94
Predict pI for various phosphorylation states
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