SLC6A12 Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily. Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 6|6 F1
Cellular Component:  integral component of membrane; integral component of plasma membrane; membrane; neuron projection; plasma membrane
Molecular Function:  gamma-aminobutyric acid:sodium symporter activity; neurotransmitter binding; neurotransmitter:sodium symporter activity; symporter activity
Biological Process:  cellular water homeostasis; neurotransmitter transport
Reference #:  Q8VCS9 (UniProtKB)
Alt. Names/Synonyms: BGT1; Gabt; Gabt2; gamma-aminobutyric acid (GABA-A) transporter 2; GAT-2; Gat2; Na(+)/Cl(-) betaine/GABA transporter; S6A12; Slc6a12; Sodium- and chloride-dependent betaine transporter; Sodium- and chloride-dependent GABA transporter 2; solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12; Solute carrier family 6 member 12; Transporter
Gene Symbols: Slc6a12
Molecular weight: 71,220 Da
Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein