MLK1 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; MLK family; MLK subfamily; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 12|12 D1
Cellular Component: 
Molecular Function:  ATP binding; JUN kinase kinase kinase activity; kinase activity; MAP kinase kinase kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of JUN kinase activity; apoptotic process; cell death; MAPK cascade; phosphorylation; positive regulation of apoptotic process; protein autophosphorylation; protein phosphorylation
Reference #:  Q3U1V8 (UniProtKB)
Alt. Names/Synonyms: E130314H24Rik; M3K9; Map3k9; mitogen activated protein kinase kinase kinase 9; Mitogen-activated protein kinase kinase kinase 9; Mlk; Mlk1; Prke1
Gene Symbols: Map3k9
Molecular weight: 118,805 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MLK1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene