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F13A1
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Belongs to the transglutaminase superfamily. Transglutaminase family. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.3.2.13; Transferase |
| Chromosomal Location of human Ortholog: 6p25.1 |
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Cellular Component:
extracellular region; extracellular space; platelet alpha granule lumen; transferase complex
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Molecular Function:
metal ion binding; protein binding; protein-glutamine gamma-glutamyltransferase activity
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Biological Process:
blood coagulation; blood coagulation, fibrin clot formation; peptide cross-linking
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Disease: Factor Xiii, A Subunit, Deficiency Of; Myocardial Infarction, Susceptibility To; Thrombophilia Due To Thrombin Defect
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Reference #:
P00488
(UniProtKB)
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Alt. Names/Synonyms: bA525O21.1 (coagulation factor XIII, A1 polypeptide); Coagulation factor XIII A chain; coagulation factor XIII A1 subunit; coagulation factor XIII, A polypeptide; coagulation factor XIII, A1 polypeptide; Coagulation factor XIIIa; F13A; F13A1; factor XIIIa; fibrin stabilizing factor, A subunit; fibrinoligase; FSF, A subunit; Protein-glutamine gamma-glutamyltransferase A chain; TGase; Transglutaminase A chain; transglutaminase. plasma
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Gene Symbols: F13A1
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Molecular weight:
83,268 Da
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Basal Isoelectric point:
5.69
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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