IFNAR2 Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Belongs to the type II cytokine receptor family. Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component:  extracellular region; integral component of plasma membrane; plasma membrane
Molecular Function:  protein binding; protein kinase binding; type I interferon receptor activity
Biological Process:  cell surface receptor signaling pathway; defense response to virus; JAK-STAT cascade; regulation of type I interferon-mediated signaling pathway; response to interferon-alpha; response to interferon-beta; response to virus; type I interferon signaling pathway
Disease: Hepatitis B Virus, Susceptibility To; Immunodeficiency 45
Reference #:  P48551 (UniProtKB)
Alt. Names/Synonyms: human interferon alpha/beta receptor; IFN-alpha-REC; IFN-alpha/beta receptor 2; IFN-R; IFN-R-2; IFNABR; IFNAR2; IFNARB; INAR2; interferon (alpha, beta and omega) receptor 2; Interferon alpha/beta receptor 2; interferon-alpha/beta receptor beta chain; Type I interferon receptor 2
Gene Symbols: IFNAR2
Molecular weight: 57,759 Da
Basal Isoelectric point: 4.37  Predict pI for various phosphorylation states
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IFNAR2

Protein Structure Not Found.


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