TORC2 Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). Belongs to the TORC family. Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 3|3 F1
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  cAMP response element binding protein binding; chromatin binding; protein binding
Biological Process:  gluconeogenesis; glucose homeostasis; histone H3-K9 acetylation; positive regulation of CREB transcription factor activity; positive regulation of transcription by RNA polymerase II; protein homotetramerization; toxin transport
Reference #:  Q3U182 (UniProtKB)
Alt. Names/Synonyms: 4632407F12Rik; CREB regulated transcription coactivator 2; CREB-regulated transcription coactivator 2; Crtc2; mTORC2; OTTMUSP00000023505; TORC-2; Torc2; Transducer of CREB protein 2; Transducer of regulated cAMP response element-binding protein 2
Gene Symbols: Crtc2
Molecular weight: 73,216 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
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TORC2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene