WAVE2 Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Belongs to the SCAR/WAVE family. Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component:  actin cytoskeleton; cell-cell junction; cytosol; early endosome; lamellipodium; protein-containing complex; ruffle; SCAR complex; synapse
Molecular Function:  actin binding; protein binding; protein kinase A binding; SH3 domain binding
Biological Process:  actin cytoskeleton organization; actin filament-based movement; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; ameboidal-type cell migration; angiogenesis; endocytosis; Fc-gamma receptor signaling pathway involved in phagocytosis; lamellipodium assembly; lamellipodium morphogenesis; megakaryocyte development; negative regulation of stress fiber assembly; positive regulation of lamellipodium assembly; postsynaptic actin cytoskeleton organization; Rac protein signal transduction; vascular endothelial growth factor receptor signaling pathway; viral process
Reference #:  Q9Y6W5 (UniProtKB)
Alt. Names/Synonyms: dJ393P12.2; IMD2; Protein WAVE-2; putative Wiskott-Aldrich syndrome protein family member 4; SCAR2; suppressor of cyclic-AMP receptor (WASP-family); Verprolin homology domain-containing protein 2; WAS protein family member 2; WAS protein family, member 2; WASF2; WASF4; WASP family member 2; WASP family protein member 2; WASP family protein member 4; WASP family Verprolin-homologous protein 2; WAVE2; Wiskott-Aldrich syndrome protein family member 2
Gene Symbols: WASF2
Molecular weight: 54,284 Da
Basal Isoelectric point: 5.38  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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