PLM a protein of the FXYD family of small ion transport regulators or channels. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May have a functional role in muscle contraction. Major plasma membrane substrate for PKA and PKC in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation.Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Channel, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7|7 B1
Cellular Component:  apical plasma membrane; caveola; integral component of membrane; intercalated disc; membrane; plasma membrane; sarcolemma; T-tubule
Molecular Function:  ATPase binding; ion channel regulator activity; myosin binding; sodium channel regulator activity
Biological Process:  ion transport; positive regulation of inorganic anion transmembrane transport; positive regulation of organic acid transport; positive regulation of sodium ion export across plasma membrane; potassium ion transport; regulation of cardiac muscle cell contraction; regulation of cardiac muscle cell membrane potential; regulation of cytosolic calcium ion concentration; regulation of ion transport; regulation of sodium ion transmembrane transporter activity; sodium ion transport
Reference #:  Q9Z239 (UniProtKB)
Alt. Names/Synonyms: 0610012C17Rik; 1110006M24Rik; FXYD domain-containing ion transport regulator 1; Fxyd1; Phospholemman; Plm; Pml
Gene Symbols: Fxyd1
Molecular weight: 10,323 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene