PKLR Plays a key role in glycolysis. Belongs to the pyruvate kinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC; Kinase, other; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 3 F1|3 39.01 cM
Cellular Component:  cytoplasm; cytosol; plasma membrane
Molecular Function:  ATP binding; catalytic activity; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; potassium ion binding; pyruvate kinase activity; transferase activity
Biological Process:  ATP biosynthetic process; carbohydrate metabolic process; cellular response to insulin stimulus; glycolytic process; metabolic process; phosphorylation; pyruvate biosynthetic process; response to ATP; response to cAMP; response to heat; response to lithium ion; response to other organism
Reference #:  P53657 (UniProtKB)
Alt. Names/Synonyms: KPYR; L-PK; OTTMUSP00000019089; Pk-1; Pk1; Pklr; Pyruvate kinase isozymes R/L; pyruvate kinase liver and red blood cell; Pyruvate kinase PKLR; R-PK
Gene Symbols: Pklr
Molecular weight: 62,309 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene