PKLR Plays a key role in glycolysis. Belongs to the pyruvate kinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC; Kinase, other; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 1q22
Cellular Component:  cytosol
Molecular Function:  ATP binding; kinase activity; magnesium ion binding; potassium ion binding; pyruvate kinase activity
Biological Process:  ATP biosynthetic process; canonical glycolysis; cellular response to epinephrine stimulus; pyruvate biosynthetic process; response to ATP; response to cAMP; response to glucose; response to heat; response to hypoxia; response to lithium ion
Disease: Adenosine Triphosphate, Elevated, Of Erythrocytes; Pyruvate Kinase Deficiency Of Red Cells
Reference #:  P30613 (UniProtKB)
Alt. Names/Synonyms: KPYR; PK1; PKL; PKLR; PKR; PKRL; Pyruvate kinase 1; pyruvate kinase isozyme R/L; Pyruvate kinase isozymes R/L; Pyruvate kinase PKLR; pyruvate kinase type L; pyruvate kinase, liver and blood cell; pyruvate kinase, liver and RBC; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase; RPK
Gene Symbols: PKLR
Molecular weight: 61,830 Da
Basal Isoelectric point: 7.65  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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