PKLR
Plays a key role in glycolysis. Belongs to the pyruvate kinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; Kinase, other; Nucleotide Metabolism - purineChromosomal Location of human Ortholog: 1q22
Cellular Component:
cytoplasm; cytosol
Molecular Function:
ATP binding; kinase activity; magnesium ion binding; monosaccharide binding; potassium ion binding; protein binding; pyruvate kinase activity
Biological Process:
cellular response to epinephrine stimulus; cellular response to insulin stimulus; glycolytic process; phosphorylation; pyruvate biosynthetic process; response to ATP; response to cAMP; response to glucose; response to hypoxia; response to metal ion; response to nutrient
Disease: Adenosine Triphosphate, Elevated, Of Erythrocytes ; Pyruvate Kinase Deficiency Of Red Cells
Reference #:
P30613
(UniProtKB)
Alt. Names/Synonyms: KPYR; PK1; PKL; PKLR; PKR; PKRL; Pyruvate kinase 1; pyruvate kinase isozyme R/L; Pyruvate kinase isozymes L/R; Pyruvate kinase isozymes R/L; pyruvate kinase L/R; Pyruvate kinase PKLR; pyruvate kinase type L; pyruvate kinase, liver and blood cell; pyruvate kinase, liver and RBC; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase; RPK
Gene Symbols: PKLR
Molecular weight:
61,830 Da
Basal Isoelectric point:
7.65
Predict pI for various phosphorylation states
Select Structure to View Below
PKLR
1LIU - A/B/C/D=47-574 (human)
1LIW - A/B/C/D=47-574 (human)
1LIX - A/B/C/D=47-574 (human)
1LIY - A/B/C/D=47-574 (human)
2VGB - A/B/C/D=47-574 (human)
2VGF - A/B/C/D=47-574 (human)
2VGG - A/B/C/D=47-574 (human)
2VGI - A/B/C/D=47-574 (human)
4IMA - A/B/C/D=34-574 (human)
4IP7 - A/D/C/B=1-543 (human)
5SC8 - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SC9 - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SCA - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SCB - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SCC - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SCD - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SCE - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SCF - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SCG - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SCH - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SCI - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SCJ - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SCK - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SCL - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
5SDT - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
6NN4 - A/D/C/B=34-574 (human)
6NN5 - A/D/C/B=34-574 (human)
6NN7 - F/A/E/B/H/C/D/G=34-574 (human)
6NN8 - F/A/E/B/H/C/D/G=34-574 (human)
7FRV - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FRW - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FRX - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FRY - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FRZ - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FS0 - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FS1 - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FS2 - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FS3 - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FS4 - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FS5 - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FS6 - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FS7 - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FS8 - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FS9 - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FSA - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FSB - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FSC - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7FSD - A/B/C/D/E/F/G/H=34-160, A/B/C/D/E/F/G/H=262-574 (human)
7QDN - A/B/C/D/E/F/G/H=30-574 (human)
7QZU - A/B/C/D/E/F/G/H=30-574 (human)
8TBS - A/B/C/D/E/F/G/H=50-574 (human)
8TBT - A/B/C/D=50-574 (human)
8TBU - A/B/C/D/E/F/G/H=50-574 (human)
8XFD - A/B/C/D=34-574 (human)
6ECH - A/D/C/B=1-543 (rat)
6ECK - A/B=1-543 (rat)
