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SOCS1
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. Belongs to the SOCS1 family. Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor |
| Chromosomal Location of mouse Ortholog: 16 A1|16 5.81 cM |
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Cellular Component:
cytoplasmic ribonucleoprotein granule; cytoplasmic vesicle; cytosol; nucleoplasm; nucleus; phosphatidylinositol 3-kinase complex
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Molecular Function:
1-phosphatidylinositol-3-kinase regulator activity; insulin-like growth factor receptor binding; kinase inhibitor activity; protein binding; protein kinase binding
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Biological Process:
cellular response to amino acid stimulus; cellular response to cytokine stimulus; cellular response to organic cyclic compound; cytokine-mediated signaling pathway; fat cell differentiation; intracellular signal transduction; macrophage differentiation; negative regulation of CD8-positive, alpha-beta T cell differentiation; negative regulation of hepatic stellate cell proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of signal transduction; negative regulation of tyrosine phosphorylation of STAT protein; phosphatidylinositol phosphate biosynthetic process; positive regulation of CD4-positive, alpha-beta T cell differentiation; positive regulation of fibroblast apoptotic process; positive regulation of regulatory T cell differentiation; receptor signaling pathway via JAK-STAT; regulation of activation of Janus kinase activity; regulation of cytokine production; regulation of protein phosphorylation; regulation of receptor signaling pathway via JAK-STAT; regulation of tyrosine phosphorylation of STAT protein
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Reference #:
O35716
(UniProtKB)
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Alt. Names/Synonyms: Cis; Cish1; Cish7; cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; JAB; JAK-binding protein; JAK2-binding protein; SOC; SOCS-1; Socs1; SSI-1; Ssi1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1
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Gene Symbols: Socs1
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Molecular weight:
23,715 Da
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Basal Isoelectric point:
11.11
Predict pI for various phosphorylation states
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CST Pathways:
IL6 Signaling
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Toll-Like Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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