Mnk2 Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; MAPKAPK family; MNK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  nuclear body; nucleoplasm; PML body
Molecular Function:  ATP binding; metal ion binding; protein binding; protein serine/threonine kinase activity
Biological Process:  cell surface receptor signaling pathway; cellular response to arsenic-containing substance; extrinsic apoptotic signaling pathway in absence of ligand; hemopoiesis; intracellular signal transduction; protein phosphorylation; regulation of translation
Reference #:  Q9HBH9 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor kinase 7; GPRK7; MAP kinase interacting serine/threonine kinase 2; MAP kinase signal-integrating kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; MAPK interacting serine/threonine kinase 2; MAPK signal-integrating kinase 2; MKNK2; MNK2; Putative map kinase interacting kinase
Gene Symbols: MKNK2
Molecular weight: 51,875 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs  |  Translation: eIF4E and p70S6K
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Mnk2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein