|
Mnk2
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; MAPKAPK family; MNK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation |
| Chromosomal Location of human Ortholog: 19p13.3 |
|
Cellular Component:
cytoplasm; nuclear body; nucleoplasm; nucleus; PML body
|
|
Molecular Function:
ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; metal ion binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
|
|
Biological Process:
cell surface receptor signaling pathway; cellular response to arsenic-containing substance; extrinsic apoptotic signaling pathway in absence of ligand; hemopoiesis; intracellular signal transduction; peptidyl-serine phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of translation
|
|
Reference #:
Q9HBH9
(UniProtKB)
|
|
Alt. Names/Synonyms: G protein-coupled receptor kinase 7; GPRK7; MAP kinase interacting serine/threonine kinase 2; MAP kinase signal-integrating kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; MAPK interacting serine/threonine kinase 2; MAPK signal-integrating kinase 2; MKNK2; MNK2; Putative map kinase interacting kinase
|
|
Gene Symbols: MKNK2
|
|
Molecular weight:
51,875 Da
|
|
Basal Isoelectric point:
5.8
Predict pI for various phosphorylation states
|
|
CST Pathways:
Angiogenesis
|
Growth And Differentiation Control by MAPKs
|
Regulation of P38 MAPKs
|
Translation: eIF4E and p70S6K
|
