TLE1 Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. Belongs to the WD repeat Groucho/TLE family. In all tissues examined, mostly in brain, liver and muscle. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 4|4 C3
Cellular Component:  beta-catenin-TCF complex; cytoplasm; cytosol; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  chromatin binding; identical protein binding; protein binding; repressing transcription factor binding; transcription corepressor activity; transcription factor binding
Biological Process:  negative regulation of anoikis; negative regulation of canonical Wnt signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of gene expression; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; Wnt signaling pathway
Reference #:  Q62440 (UniProtKB)
Alt. Names/Synonyms: C230057C06Rik; Estm1; Estm14; Grg; Grg-1; Grg1; Groucho-related protein 1; OTTMUSP00000000387; RP24-535M24.1; Tle; Tle1; Tle4-like; Tle4l; transducin-like enhancer of split 1; transducin-like enhancer of split 1, homolog of Drosophila E(spl); transducin-like enhancer of split 4 (homolog of Drosophila E(spl)) - like; Transducin-like enhancer protein 1
Gene Symbols: Tle1
Molecular weight: 83,097 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA