MLK2 Activates the JUN N-terminal pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Expressed in brain and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; MLK family; MLK subfamily; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of human Ortholog: 19q13.2
Cellular Component:  cytoplasm
Molecular Function:  ATP binding; bHLH transcription factor binding; JUN kinase kinase kinase activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transcription corepressor activity
Biological Process:  activation of JNKK activity; activation of JUN kinase activity; apoptotic process; JNK cascade; negative regulation of DNA-binding transcription factor activity; negative regulation of transcription, DNA-templated; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of JNK cascade; positive regulation of JUN kinase activity; protein autophosphorylation; signal transduction; smoothened signaling pathway
Reference #:  Q02779 (UniProtKB)
Alt. Names/Synonyms: M3K10; MAP3K10; MEKK10; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MLK2; MST; Protein kinase MST
Gene Symbols: MAP3K10
Molecular weight: 103,694 Da
Basal Isoelectric point: 6.56  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
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MLK2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene