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MLK2
Activates the JUN N-terminal pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Expressed in brain and skeletal muscle. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.25; Kinase, protein; MLK family; MLK subfamily; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group |
| Chromosomal Location of human Ortholog: 19q13.2 |
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Cellular Component:
cytoplasm
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Molecular Function:
ATP binding; bHLH transcription factor binding; JUN kinase kinase kinase activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transcription corepressor activity
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Biological Process:
activation of JNKK activity; activation of JUN kinase activity; apoptotic process; JNK cascade; negative regulation of DNA-binding transcription factor activity; negative regulation of transcription, DNA-templated; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of JNK cascade; positive regulation of JUN kinase activity; protein autophosphorylation; signal transduction; smoothened signaling pathway
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Reference #:
Q02779
(UniProtKB)
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Alt. Names/Synonyms: M3K10; MAP3K10; MEKK10; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MLK2; MST; Protein kinase MST
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Gene Symbols: MAP3K10
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Molecular weight:
103,694 Da
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Basal Isoelectric point:
6.56
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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Regulation of P38 MAPKs
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SAPK/JNK Signaling Cascades
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