GJA5 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Alpha-type (group II) subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3 F2.1|3 42.04 cM
Cellular Component:  cell junction; cell projection; connexin complex; gap junction; integral component of membrane; integral component of plasma membrane; intercalated disc; membrane; plasma membrane
Molecular Function:  connexin binding; disordered domain specific binding; gap junction channel activity; gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling; gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling; gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling; gap junction channel activity involved in cardiac conduction electrical coupling; gap junction hemi-channel activity
Biological Process:  artery morphogenesis; atrial cardiac muscle cell to AV node cell communication by electrical coupling; atrial septum development; atrial septum morphogenesis; atrial ventricular junction remodeling; AV node cell to bundle of His cell communication; AV node cell to bundle of His cell communication by electrical coupling; blood vessel development; bundle of His cell to Purkinje myocyte communication by electrical coupling; cardiac conduction; cardiac conduction system development; cell communication; cell communication by chemical coupling; cell communication by electrical coupling; cell communication by electrical coupling involved in cardiac conduction; cell communication involved in cardiac conduction; embryonic heart tube development; embryonic limb morphogenesis; foramen ovale closure; gap junction assembly; mitral valve development; negative regulation of blood pressure; negative regulation of glomerular filtration; outflow tract morphogenesis; positive regulation of blood vessel diameter; positive regulation of cell communication by chemical coupling; positive regulation of vasoconstriction; potassium ion transport; protein complex oligomerization; pulmonary valve formation; regulation of atrial cardiac muscle cell action potential; regulation of atrial cardiac muscle cell membrane depolarization; regulation of AV node cell action potential; regulation of blood vessel diameter; regulation of bundle of His cell action potential; regulation of cardiac muscle contraction; regulation of heart rate by cardiac conduction; regulation of membrane depolarization during cardiac muscle cell action potential; regulation of Purkinje myocyte action potential; regulation of renin secretion into blood stream; regulation of systemic arterial blood pressure; regulation of ventricular cardiac muscle cell membrane depolarization; regulation of ventricular cardiac muscle cell membrane repolarization; renal system process involved in regulation of systemic arterial blood pressure; SA node cell action potential; septum primum development; skeletal system development; vasomotion; ventricular cardiac muscle cell action potential; ventricular septum development; ventricular septum morphogenesis
Reference #:  Q01231 (UniProtKB)
Alt. Names/Synonyms: 5730555N10Rik; Cnx40; connexin 40; connexin i; Connexin-40; Cx40; CXA5; Cxn-40; Cxni; Gap junction alpha-5 protein; gap junction membrane channel protein alpha 5; gap junction protein, alpha 5; Gja-; Gja-5; Gja5; OTTMUSP00000024800
Gene Symbols: Gja5
Molecular weight: 40,413 Da
Basal Isoelectric point: 8.48  Predict pI for various phosphorylation states
Select Structure to View Below

GJA5

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene