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SIAT7F
Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)). Belongs to the glycosyltransferase 29 family. Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.4.99.-; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Membrane protein, integral; Transferase |
| Chromosomal Location of mouse Ortholog: 2|2 B |
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Cellular Component:
cytoplasm; Golgi apparatus; membrane
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Molecular Function:
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity; glycosyltransferase activity; sialyltransferase activity; transferase activity
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Biological Process:
cell-cell recognition; ganglioside biosynthetic process; glycoprotein metabolic process; glycosphingolipid metabolic process; glycosylceramide metabolic process; lipid metabolic process; oligosaccharide biosynthetic process; oligosaccharide metabolic process; protein glycosylation
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Reference #:
Q9JM95
(UniProtKB)
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Alt. Names/Synonyms: (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; GalNAc alpha-2,6-sialyltransferase VI; OTTMUSP00000012855; Sia; SIA7F; Sialyltransferase 7F; sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F; sialytransferase 7 (alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F; SIAT7-F; Siat7f; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6G; ST6GalNAc VI; St6galnac6; ST6GalNAcVI
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Gene Symbols: St6galnac6
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Molecular weight:
38,167 Da
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Basal Isoelectric point:
9.79
Predict pI for various phosphorylation states
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| Select Structure to View Below |
SIAT7F
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