SIAT7F Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)). Belongs to the glycosyltransferase 29 family. Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.99.-; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component:  cytoplasm; Golgi membrane; integral component of membrane; plasma membrane
Molecular Function:  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity; sialyltransferase activity
Biological Process:  cell-cell recognition; ganglioside biosynthetic process; glycoprotein metabolic process; glycosphingolipid metabolic process; glycosylceramide metabolic process; oligosaccharide biosynthetic process; protein glycosylation; sialylation
Reference #:  Q969X2 (UniProtKB)
Alt. Names/Synonyms: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI; GalNAc alpha-2,6-sialyltransferase VI; hST6GalNAc VI; RP11-203J24.3; SIA7F; Sialyltransferase 7F; sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F; SIAT7-F; SIAT7F; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc VI; ST6GALNAC6; ST6GalNAcVI
Gene Symbols: ST6GALNAC6
Molecular weight: 38,068 Da
Basal Isoelectric point: 9.91  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene