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SIAT7F
Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)). Belongs to the glycosyltransferase 29 family. Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.4.99.-; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Membrane protein, integral; Transferase |
| Chromosomal Location of human Ortholog: 9q34.11 |
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Cellular Component:
cytoplasm; Golgi membrane; membrane; plasma membrane
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Molecular Function:
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity; protein binding; sialyltransferase activity
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Biological Process:
cell-cell recognition; ganglioside biosynthetic process; glycoprotein metabolic process; glycosphingolipid metabolic process; glycosylceramide metabolic process; oligosaccharide biosynthetic process; oligosaccharide metabolic process; protein glycosylation
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Reference #:
Q969X2
(UniProtKB)
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Alt. Names/Synonyms: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI; epididymis secretory sperm binding protein; GalNAc alpha-2,6-sialyltransferase VI; hST6GalNAc VI; RP11-203J24.3; SIA7F; Sialyltransferase 7F; sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F; SIAT7-F; SIAT7F; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6 -N-acetylgalactosaminide alpha-26-sialyltransferase 6; ST6 GalNAc alpha-2,6-sialyltransferase 6; ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc VI; ST6GALNAC6; ST6GalNAcVI
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Gene Symbols: ST6GALNAC6
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Molecular weight:
38,068 Da
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Basal Isoelectric point:
9.91
Predict pI for various phosphorylation states
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